JAK and STAT Signaling Molecules in Immunoregulation and Immune-Mediated Disease

JAK-STAT signaling in human disease

Numerous examples indicate that mammalian development can be entirely normal in the absence of the immune system; indeed, prior to birth, individuals with even very severe immunodeficiencies are developmentally unaffected. Perhaps it is not surprising, therefore, that more than 95 different primary immunodeficiency syndromes have been identified, encompassing defects in lymphocytes, phagocytes,...

JAK-STAT signaling in human disease

The past two decades have witnessed a dramatic increase in the prevalence of asthma worldwide (1). Asthma is a chronic disease characterized by variable airway obstruction, airway hyperresponsiveness (AHR), and airway inflammation and remodeling. Histological studies show that airways of asthmatic patients contain a chronic inflammatory infiltrate composed of lymphocytes, eosinophils, and mast ...

JAK-STAT signaling in human disease

Innate immune responses derive from the ability of cells to rapidly combat invading microorganisms without the requirement for an antigen-specific adaptation. These mechanisms have evolved to recognize common microbe-associated molecular patterns and to interfere with conserved replication and survival strategies that support the propagation of microbial invaders. Here, we consider the contribu...

The Jak-Stat Signaling Pathway of Interferons System: Snapshots

Interferons (IFNs) are a family of small regulatory glycoproteins that play a central role in the defense against viral infections. Although IFNs have been initially discovered as antiviral factors, today they are known as an integral part of the cytokine network that affect a wide range of biological processes. IFNs exert their pleiotropic effects through their multisubunit cell surface recept...

SnapShot: JAK-STAT Signaling